Transferring to another type or brand, changes in strength, species, &/or method of manufacture. Less pronounced or different early warning symptoms of hypoglycemia in conditions including long duration of diabetes, diabetic nerve disease, medications (eg, β-blockers). Inadequate use of dosages or discontinuation of treatment may lead to hyperglycemia & diabetic ketoacidosis especially in insulin-dependent diabetics. Uncorrected hypoglycemic & hyperglycemic reactions. Increased insulin requirements during illness or emotional disturbances. Change in insulin requirements in diseases of the adrenal, pituitary or thyroids glands & in the presence of renal or hepatic impairment; during illness or emotional disturbances; change in the level of physical activity or usual diet. Instruct patients to perform continuous rotation of the inj site to reduce the risk of developing lipodystrophy & cutaneous amyloidosis. Observe for signs & symptoms of heart failure, wt gain & edema if used in combination w/ pioglitazone; discontinue if any deterioration in cardiac symptoms occurs. May impair ability to drive or operate machinery. Pregnancy & lactation.
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